Association Study of Genetic Variants in Calcium Signaling-Related Genes With Cardiovascular Diseases.

ABSTRACT: Background: Calcium ions (Ca²⁺) play an essential role in excitation-contraction coupling in the heart. The association between cardiovascular diseases (CVDs) and genetic polymorphisms in key regulators of Ca²⁺ homeostasis is well established but still inadequately understood. Methods: The associations of 11,274 genetic variants located in nine calcium signaling-related genes with 118 diseases of the circulatory system were explored using a large sample from the United Kingdom Biobank (N = 308,366). The clinical outcomes in electronic health records were mapped to the phecode system. Survival analyses were employed to study the role of variants in CVDs incidence and mortality. Phenome-wide association studies (PheWAS) were performed to investigate

SUBMITTER: Li S 

PROVIDER: S-EPMC8666440 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature