Dataset Information

Human Immunotypes Impose Selection on Viral Genotypes Through Viral Epitope Specificity.

ABSTRACT:

Background

Understanding the genetic interplay between human hosts and infectious pathogens is crucial for how we interpret virulence factors. Here, we tested for associations between HIV and host genetics, and interactive genetic effects on viral load (VL) in HIV-positive antiretroviral treatment-naive clinical trial participants.

Methods

HIV genomes were sequenced and the encoded amino acid (AA) variants were associated with VL, human single nucleotide polymorphisms (SNPs), and imputed HLA alleles using generalized linear models with Bonferroni correction.

Results

Human (388 501 SNPs) and HIV (3010 variants) genetic data were available for 2122 persons. Four HIV variants were associated with VL (P < 1.66 × 10-5). Twelve HIV variants were associated with a range of 1-512 human SNPs (P < 4.28 × 10-11). We found 46 associations between HLA alleles and HIV variants (P < 1.29 × 10-7). HIV variants and immunotypes when analyzed separately were associated with lower VL, whereas the opposite was true when analyzed in concert. Epitope binding predictions supported our observations.

Conclusions

Our results show the importance of immunotype specificity on viral antigenic determinants, and the identified genetic interplay emphasizes that viral and human genetics should be studied in the context of each other.Clinical Trials Registration: NCT00867048.

SUBMITTER: Gabrielaite M

PROVIDER: S-EPMC8672757 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Publications

Human Immunotypes Impose Selection on Viral Genotypes Through Viral Epitope Specificity.

Gabrielaite Migle M Bennedbæk Marc M Zucco Adrian G AG Ekenberg Christina C Murray Daniel D DD Kan Virginia L VL Touloumi Giota G Vandekerckhove Linos L Turner Dan D Neaton James J Lane H Clifford HC Safo Sandra S Arenas-Pinto Alejandro A Polizzotto Mark N MN Günthard Huldrych F HF Lundgren Jens D JD Marvig Rasmus L RL

The Journal of infectious diseases 20211201 12

<h4>Background</h4>Understanding the genetic interplay between human hosts and infectious pathogens is crucial for how we interpret virulence factors. Here, we tested for associations between HIV and host genetics, and interactive genetic effects on viral load (VL) in HIV-positive antiretroviral treatment-naive clinical trial participants.<h4>Methods</h4>HIV genomes were sequenced and the encoded amino acid (AA) variants were associated with VL, human single nucleotide polymorphisms (SNPs), and ...[more]

PMID: 33974707

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Dataset Information

Human Immunotypes Impose Selection on Viral Genotypes Through Viral Epitope Specificity.

Background

Methods

Results

Conclusions

Publications

Human Immunotypes Impose Selection on Viral Genotypes Through Viral Epitope Specificity.

Similar Datasets

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