Human Immunotypes Impose Selection on Viral Genotypes Through Viral Epitope Specificity.

ABSTRACT:

Background

Understanding the genetic interplay between human hosts and infectious pathogens is crucial for how we interpret virulence factors. Here, we tested for associations between HIV and host genetics, and interactive genetic effects on viral load (VL) in HIV-positive antiretroviral treatment-naive clinical trial participants.

Methods

HIV genomes were sequenced and the encoded amino acid (AA) variants were associated with VL, human single nucleotide polymorphisms (SNPs), and imputed HLA alleles using generalized linear models with Bonferroni correction.

Results

Human (388 501 SNPs) and HIV (3010 variants) genetic data were available for 2122 persons. Four HIV variants were associated with VL (P < 1.66 × 10-5). Twelve HIV variants were associated with a range of 1

SUBMITTER: Gabrielaite M 

PROVIDER: S-EPMC8672757 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature