Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population.

ABSTRACT: Although there have been many studies of gene variant association with different stages of HIV/AIDS progression in United States and European cohorts, few gene-association studies have assessed genic determinants in sub-Saharan African populations, which have the highest density of HIV infections worldwide. We carried out genome-wide association studies on 766 study participants at risk for HIV-1 subtype C (HIV-1C) infection in Botswana. Three gene associations (AP3B1, PTPRA, and NEO1) were shown to have significant association with HIV-1C acquisition. Each gene association was replicated within Botswana or in the United States-African American or United States-European American AIDS cohorts or in both. Each associated gene has a prior reported influence on HIV/AIDS pa

SUBMITTER: Shevchenko AK 

PROVIDER: S-EPMC8672799 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature