Acute FPIES reactions are associated with an IL-17 inflammatory signature.

ABSTRACT:

Background

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy characterized by profuse vomiting within hours of ingestion of the causative food. We have previously reported that FPIES is associated with systemic innate immune activation in the absence of a detectable antigen-specific antibody or T-cell response. The mechanism of specific food recognition by the immune system remains unclear.

Objective

Our aim was to identify immune mechanisms underlying FPIES reactions by proteomic and flow cytometric analysis of peripheral blood.

Methods

Children with a history of FPIES underwent supervised oral food challenge. Blood samples were taken at baseline, at symptom onset, and 4 hours after symptom onset. We analyzed samples from 23 child

SUBMITTER: Berin MC 

PROVIDER: S-EPMC8675150 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature