Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume.

ABSTRACT: The volume of subcortical structures represents a reliable, quantitative, and objective phenotype that captures genetic effects, environmental effects such as trauma, and disease effects such as posttraumatic stress disorder (PTSD). Trauma and PTSD represent potent exposures that may interact with genetic markers to influence brain structure and function. Genetic variants, associated with subcortical volumes in two large normative discovery samples, were used to compute polygenic scores (PGS) for the volume of seven subcortical structures. These were applied to a target sample enriched for childhood trauma and PTSD. Subcortical volume PGS from the discovery sample were strongly associated in our trauma/PTSD enriched sample (n = 7580) with respective subcortical volumes of the hippocampus (

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC8677780 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature