Fecal Microbial Transplant in Individuals With Immune-Mediated Dry Eye.

ABSTRACT:

Purpose

To evaluate the safety of the Fecal Microbial Transplant for Sjogren Syndrome (FMT) trial in individuals with immune-mediated dry eye (DE).

Design

Open-label, nonrandomized clinical trial.

Methods

The study population included 10 individuals with DE symptoms and signs meeting criteria for Sjögren or positive early Sjögren markers. Procedures were 2 FMTs from a single healthy donor delivered via enema, 1 week apart. The primary outcome measure was safety. In addition, gut microbiome profiles, DE metrics, and T-cell profiles in blood were examined at baseline before FMT, and at 1 week, 1 month, and 3 months after FMT.

Results

The mean age of the population was 60.4 years; 30% were male; 50% were white; and 50% were Hispanic. At baseline, all subjects had

SUBMITTER: Watane A 

PROVIDER: S-EPMC8678170 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature