Metformin use and cardiovascular outcomes in patients with diabetes and chronic kidney disease: a nationwide cohort study.

ABSTRACT:

Background

Metformin has recently been shown not to increase the risk of lactic acidosis in patients with chronic kidney disease (CKD). Thus, the criteria for metformin use in this population has expanded. However, the relationship between metformin use and clinical outcomes in CKD remains controversial.

Methods

This study considered data from 97,713 diabetes patients with an estimated glomerular filtration rate of <60 mL/min/1.73 m2. The primary outcome was major adverse cardiac and cerebrovascular events (MACCE), and the secondary outcomes were all-cause mortality and incident end-stage renal disease (ESRD).

Results

Metformin users had a significantly higher risk of MACCE than non-users (hazard ratio [HR], 1.20; 95% confidence interval [CI], 1.14-1.26; p < 0.001). H

SUBMITTER: Kim MH 

PROVIDER: S-EPMC8685353 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature