Comparative effectiveness of common treatments for new-onset atrial fibrillation within the ICU: Accounting for physiological status.

ABSTRACT:

Background

New-onset atrial fibrillation (NOAF) is common in patients on an intensive care unit (ICU). Evidence guiding treatments is limited, though recent reports suggest beta blocker (BB) therapy is associated with reduced mortality.

Methods

We conducted a multicentre cohort study of adult patients admitted to 3 ICUs in the UK and 5 ICUs in the USA. We analysed the haemodynamic changes associated with NOAF. We analysed rate control, rhythm control, and hospital mortality associated with common NOAF treatments. We balanced admission and post-NOAF, pre-treatment covariates across treatment groups.

Results

NOAF was followed by a systolic blood pressure reduction of 5 mmHg (p < 0.001). After adjustment, digoxin therapy was associated with inferior rate control versus a

SUBMITTER: Bedford JP 

PROVIDER: S-EPMC8687206 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature