Resistance Testing for Management of HIV Virologic Failure in Sub-Saharan Africa : An Unblinded Randomized Controlled Trial.

ABSTRACT:

Background

Virologic failure in HIV predicts the development of drug resistance and mortality. Genotypic resistance testing (GRT), which is the standard of care after virologic failure in high-income settings, is rarely implemented in sub-Saharan Africa.

Objective

To estimate the effectiveness of GRT for improving virologic suppression rates among people with HIV in sub-Saharan Africa for whom first-line therapy fails.

Design

Pragmatic, unblinded, randomized controlled trial. (ClinicalTrials.gov: NCT02787499).

Setting

Ambulatory HIV clinics in the public sector in Uganda and South Africa.

Patients

Adults receiving first-line antiretroviral therapy with a recent HIV RNA viral load of 1000 copies/mL or higher.

Intervention

Participants were randomly

SUBMITTER: Siedner MJ 

PROVIDER: S-EPMC8688215 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature