Detection of HIV Virologic Failure and Switch to Second-Line Therapy: A Systematic Review and Meta-analysis of Data From Sub-Saharan Africa.

ABSTRACT:

Background

The late recognition of virologic failure (VF) places persons with HIV in Sub-Saharan Africa at risk for HIV transmission, disease progression, and death. We conducted a systematic review and meta-analysis to determine if the recognition and response to VF in the region has improved.

Methods

We searched for studies reporting CD4 count at confirmed VF or at switch to second-line antiretroviral therapy (ART). Using a random-effects metaregression model, we analyzed temporal trends in CD4 count at VF-or at second-line ART switch-over time. We also explored temporal trends in delay between VF and switch to second-line ART.

Results

We identified 26 studies enrolling patients with VF and 10 enrolling patients at second-line ART switch. For studies that enrolled p

SUBMITTER: Bernabe KJ 

PROVIDER: S-EPMC9007921 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature