Absence of COVID-19-associated changes in plasma coagulation proteins and pulmonary thrombosis in the ferret model.

ABSTRACT:

Background

Many patients who are diagnosed with coronavirus disease 2019 (COVID-19) suffer from venous thromboembolic complications despite the use of stringent anticoagulant prophylaxis. Studies on the exact mechanism(s) underlying thrombosis in COVID-19 are limited as animal models commonly used to study venous thrombosis pathophysiology (i.e. rats and mice) are naturally not susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Ferrets are susceptible to SARS-CoV-2 infection, successfully used to study virus transmission, and have been previously used to study activation of coagulation and thrombosis during influenza virus infection.

Objectives

This study aimed to explore the use of (heat-inactivated) plasma and lung material from SARS-CoV-2-inocula

SUBMITTER: Kreft IC 

PROVIDER: S-EPMC8690567 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature