Aberrant functional metastability and structural connectivity are associated with rumination in individuals with major depressive disorder.

ABSTRACT: Rumination is a repetitive and compulsive thinking focusing on oneself, and the nature and consequences of distress. It is a core characteristic in psychiatric disorders characterized by affective dysregulation, and emerging evidence suggests that rumination is associated with aberrant dynamic functional connectivity and structural connectivity. However, the underlying neural mechanisms remain poorly understood. Here, we adopted a multimodal approach and tested the hypothesis that white matter connectivity forms the basis of the implications of temporal dynamics of functional connectivity in the rumination trait. Fifty-three depressed and ruminative individuals and a control group of 47 age- and gender-matched individuals with low levels of rumination underwent resting-state fMRI and diffu

SUBMITTER: Zhang R 

PROVIDER: S-EPMC8693354 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature