The functional and structural associations of aberrant microglial activity in major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is a debilitating mental illness that has been linked to increases in markers of inflammation, as well as to changes in brain functional and structural connectivity, particularly between the insula and the subgenual anterior cingulate cortex (sgACC). In this study, we directly related inflammation and dysconnectivity in treatment-resistant MDD by concurrently measuring the following: microglial activity with [¹⁸F]N-2-(fluoroethoxyl)benzyl-N-(4phenoxypyridin-3-yl)acetamide ([¹⁸F]FEPPA) positron emission tomography (PET); the severity of MDD; and functional or structural connectivity among insula or sgACC nodes.

Methods

Twelve patients with treatment-resistant MDD (8 female, 4 male; mean age ± standard deviation

SUBMITTER: Cakmak JD 

PROVIDER: S-EPMC9343118 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature