Recognition of the antigen-presenting molecule MR1 by a Vδ3⁺ γδ T cell receptor.

ABSTRACT: Unlike conventional αβ T cells, γδ T cells typically recognize nonpeptide ligands independently of major histocompatibility complex (MHC) restriction. Accordingly, the γδ T cell receptor (TCR) can potentially recognize a wide array of ligands; however, few ligands have been described to date. While there is a growing appreciation of the molecular bases underpinning variable (V)δ1⁺ and Vδ2⁺ γδ TCR-mediated ligand recognition, the mode of Vδ3⁺ TCR ligand engagement is unknown. MHC class I-related protein, MR1, presents vitamin B metabolites to αβ T cells known as mucosal-associated invariant T cells, diverse MR1-restricted T cells, and a subset of human γδ T cells. Here, we identify Vδ1/2^- γδ T cells in the blood and duodenal biopsy specimens of ch

SUBMITTER: Rice MT 

PROVIDER: S-EPMC8694053 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature