Activating Transcription Factor 3 Protects against Restraint Stress-Induced Gastrointestinal Injury in Mice.

ABSTRACT: Psychological stress increases the risk of gastrointestinal (GI) tract diseases, which involve bidirectional communication of the GI and nerves systems. Acute stress leads to GI ulcers; however, the mechanism of the native cellular protection pathway, which safeguards tissue integrality and maintains GI homeostasis, remains to be investigated. In a mouse model of this study, restraint stress induced GI leakage, abnormal tight junction protein expression, and cell death of gut epithelial cells. The expression of activating transcription factor 3 (ATF3), a stress-responsive transcription factor, is upregulated in the GI tissues of stressed animals. ATF3-deficient mice displayed an exacerbated phenotype of GI injuries. These results suggested that, in response to stress, ATF3 is part of the n

SUBMITTER: Chuang DJ 

PROVIDER: S-EPMC8700235 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature