Ontology highlight
ABSTRACT:
SUBMITTER: Seneviratne AJ
PROVIDER: S-EPMC8711017 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Seneviratne Akila J AJ Peters Sean S Clarke David D Dausmann Michael M Hecker Michael M Tully Brett B Hains Peter G PG Zhong Qing Q
Bioinformatics (Oxford, England) 20211201 24
<h4>Motivation</h4>The output of electrospray ionization-liquid chromatography mass spectrometry (ESI-LC-MS) is influenced by multiple sources of noise and major contributors can be broadly categorized as baseline, random and chemical noise. Noise has a negative impact on the identification and quantification of peptides, which influences the reliability and reproducibility of MS-based proteomics data. Most attempts at denoising have been made on either spectra or chromatograms independently, th ...[more]