Tmem100- and Acta2-Lineage Cells Contribute to Implant Osseointegration in a Mouse Model.

ABSTRACT: Metal implants are commonly used in orthopedic surgery. The mechanical stability and longevity of implants depend on adequate bone deposition along the implant surface. The cellular and molecular mechanisms underlying peri-implant bone formation (ie, osseointegration) are incompletely understood. Herein, our goal was to determine the specific bone marrow stromal cell populations that contribute to bone formation around metal implants. To do this, we utilized a mouse tibial implant model that is clinically representative of human joint replacement procedures. Using a lineage-tracing approach, we found that both Acta2.creERT2 and Tmem100.creERT2 lineage cells are involved in peri-implant bone formation, and Pdgfra- and Ly6a/Sca1-expressing stromal cells (PαS cells) are highly enriched in bot

SUBMITTER: Vesprey A 

PROVIDER: S-EPMC8715516 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature