A deletion in the N gene of SARS-CoV-2 may reduce test sensitivity for detection of SARS-CoV-2.

ABSTRACT: One SARS-CoV-2-positive sample demonstrated impaired detection of the N1 target by RT-PCR using US CDC primer/probe sets. A 3 nucleotide deletion was discovered that overlaps the forward primer binding site. This finding underscores the importance of continued SARS-CoV-2 mutation surveillance and assessment of the impact on diagnostic test performance.

SUBMITTER: Wang H 

PROVIDER: S-EPMC8715644 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature