Improving D-2-hydroxyglutarate MR spectroscopic imaging in mutant isocitrate dehydrogenase glioma patients with multiplexed RF-receive/B₀ -shim array coils at 3 T.

ABSTRACT: MR spectroscopic imaging (MRSI) noninvasively maps the metabolism of human brains. In particular, the imaging of D-2-hydroxyglutarate (2HG) produced by glioma isocitrate dehydrogenase (IDH) mutations has become a key application in neuro-oncology. However, the performance of full field-of-view MRSI is limited by B₀ spatial nonuniformity and lipid artifacts from tissues surrounding the brain. Array coils that multiplex RF-receive and B₀ -shim electrical currents (AC/DC mixing) over the same conductive loops provide many degrees of freedom to improve B₀ uniformity and reduce lipid artifacts. AC/DC coils are highly efficient due to compact design, requiring low shim currents (<2 A) that can be switched fast (0.5 ms) with high interscan reproducibility (10% coe

SUBMITTER: Strasser B 

PROVIDER: S-EPMC8717863 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature