Decompose quantitative susceptibility mapping (QSM) to sub-voxel diamagnetic and paramagnetic components based on gradient-echo MRI data.

ABSTRACT:

Purpose

A method named DECOMPOSE-QSM is developed to decompose bulk susceptibility measured with QSM into sub-voxel paramagnetic and diamagnetic components based on a three-pool complex signal model.

Methods

Multi-echo gradient echo signal is modeled as a summation of three weighted exponentials corresponding to three types of susceptibility sources: reference susceptibility, diamagnetic and paramagnetic susceptibility relative to the reference. Paramagnetic component susceptibility (PCS) and diamagnetic component susceptibility (DCS) maps are constructed to represent the sub-voxel compartments by solving for linear and nonlinear parameters in the model.

Results

Numerical forward simulation and phantom validation confirmed the ability of DECOMPOSE-QSM to separate the

SUBMITTER: Chen J 

PROVIDER: S-EPMC8720043 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature