Bamlanivimab reduces nasopharyngeal SARS-CoV-2 RNA levels but not symptom duration in non-hospitalized adults with COVID-19.
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ABSTRACT:
SUBMITTER: Chew KW
PROVIDER: S-EPMC8722620 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Bamlanivimab reduces nasopharyngeal SARS-CoV-2 RNA levels but not symptom duration in non-hospitalized adults with COVID-19: A Phase 2 Randomized Clinical Trial.
Chew Kara W KW Moser Carlee C Daar Eric S ES Wohl David A DA Li Jonathan Z JZ Coombs Robert R Ritz Justin J Giganti Mark M Javan Arzhang Cyrus AC Li Yijia Y Malvestutto Carlos C Klekotka Paul P Price Karen K Nirula Ajay A Fischer William W Bala Veenu V Ribeiro Ruy M RM Perelson Alan S AS Fletcher Courtney V CV Eron Joseph J JJ Currier Judith S JS Hughes Michael D MD Smith Davey M DM
medRxiv : the preprint server for health sciences 20211221
<h4>Importance</h4>The antiviral activity and efficacy of anti-SARS-CoV-2 monoclonal antibody (mAb) therapies to accelerate recovery from COVID-19 is important to define.<h4>Objective</h4>To determine safety and efficacy of the mAb bamlanivimab to reduce nasopharyngeal (NP) SARS-CoV-2 RNA levels and symptom duration.<h4>Design</h4>ACTIV-2/A5401 is a randomized, blinded, placebo-controlled platform trial. Two dose cohorts were enrolled between August 19 and November 17, 2020 for phase 2 evaluatio ...[more]
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