Particulate Matter Exposure Aggravates IL-17-Induced Eye and Nose Inflammation in an OVA/Poly(I:C) Mouse Model.

ABSTRACT:

Purpose

Data on the effects of direct particulate matter (PM) exposure on the eyes and the nose are limited. Here, an interleukin (IL)-17/neutrophil-dominant ovalbumin (OVA)/polyinosinic-polycytidylic acid (Poly(I:C)) mouse model was used to evaluate the effect of different-sized titanium dioxide (TiO₂) particles on the eyes and the nose. We also examined whether IL-17-neutralizing antibody (IL-17Ab) treatment could reverse TiO₂ effects.

Methods

The nasal cavities and conjunctival sacs of each mouse were challenged with OVA and Poly(I:C) to induce neutrophil-dominant inflammation and then exposed to micro- and nano-TiO₂. Subsequently, IL-17Ab was administered to investigate the role of IL-17 and inflammatory parameters.

Results

Micro-

SUBMITTER: Bae JS 

PROVIDER: S-EPMC8724832 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature