The power of genetic diversity in genome-wide association studies of lipids.

ABSTRACT: Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use¹. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels², heart disease remains the leading cause of death worldwide³. Genome-wideassociation studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS^4-23 have been conducted in European ancestry populations and may have missed genetic variants that contribute to lipid-level variation in other ancestry groups. These include differences in allele fre

SUBMITTER: Graham SE 

PROVIDER: S-EPMC8730582 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature