Antimicrobial resistance determinants are associated with <i>Staphylococcus aureus</i> bacteraemia and adaptation to the healthcare environment: a bacterial genome-wide association study.

ABSTRACT: Staphylococcus aureus is a major bacterial pathogen in humans, and a dominant cause of severe bloodstream infections. Globally, antimicrobial resistance (AMR) in S. aureus remains challenging. While human risk factors for infection have been defined, contradictory evidence exists for the role of bacterial genomic variation in S. aureus disease. To investigate the contribution of bacterial lineage and genomic variation to the development of bloodstream infection, we undertook a genome-wide association study comparing bacteria from 1017 individuals with bacteraemia to 984 adults with asymptomatic S. aureus nasal carriage. Within 984 carriage isolates, we also compared healthcare-associated (HA) carriage with community-associated (CA) carriage. All major global lin

SUBMITTER: Young BC 

PROVIDER: S-EPMC8743558 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature