Downregulation of Arntl mRNA Expression in Women with Hypertension: A Case-Control Study.

ABSTRACT:

Background

Previous studies have reported that disturbance of endogenous circadian rhythms enhances the chance of hypertension and suggested that circadian clock genes could have a crucial function in the onset of the disease. This case-control study was aimed to investigate the association of the mRNA expression of aryl hydrocarbon receptor nuclear translocator like (Arntl), clock circadian regulator (Clock), and period circadian regulators 1 and 2 (Per1 and Per2) with hypertension and blood pressure levels.

Methods

A total of 172 subjects were recruited in this study, including 86 hypertension and 86 nonhypertension controls. The mRNA expression levels in peripheral blood mononuclear cells were determined by real-time quantitative polymerase chain reaction. The differences

SUBMITTER: Fang Z 

PROVIDER: S-EPMC8743905 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature