A population-based study of scoliosis among males diagnosed with a dystrophinopathy identified by the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet).

ABSTRACT:

Introduction/aims

Scoliosis is a common comorbidity among individuals diagnosed with a dystrophinopathy. We examined associations between clinical predictors and scoliosis in childhood-onset dystrophinopathy.

Methods

The progression and treatment of scoliosis were obtained from data collected by the US population-based Muscular Dystrophy Surveillance, Tracking, and Research Network. Associations between loss of independent ambulation (LoA) and corticosteroid use and scoliosis outcomes (ages at or exceeding Cobb angle thresholds [10°, 20°, 30°]; surgery) were estimated using Kaplan-Meier curve estimation and extended Cox regression modeling.

Results

We analyzed curvature data for 513 of 1054 individuals ascertained. Overall, approximately one-half had at least one radi

SUBMITTER: Conway KM 

PROVIDER: S-EPMC8752499 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature