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Vitamin D supplementation and cardiometabolic risk factors among diverse schoolchildren: a randomized clinical trial.


ABSTRACT:

Background

There remains a lack of evidence demonstrating a potential relationship between vitamin D and cardiometabolic risk among children.

Objectives

We examined the effect of 3 different dosages of vitamin D on cardiometabolic risk factors among children at risk of deficiency.

Methods

Racially diverse schoolchildren aged 8-15 y were randomly assigned in a double-blind fashion to supplementation with 600, 1000, or 2000 IU vitamin D3/d for 6 mo. Changes in HDL cholesterol, triglycerides, LDL cholesterol, total cholesterol, and blood glucose over 6 mo and at 12 mo (6 mo post-supplementation) were assessed. Subgroup analyses were also performed by weight status and race.

Results

Among 604 children, 40.9% were vitamin D-inadequate at baseline (<20 ng/mL; mean ± 

SUBMITTER: Sacheck JM 

PROVIDER: S-EPMC8755037 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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