Patterns of Antifungal Resistance in Adult Patients With Fungal Keratitis in South India: A Post Hoc Analysis of 3 Randomized Clinical Trials.

ABSTRACT:

Importance

Antifungal resistance has been shown to impact treatment success, but research analyzing antifungal resistance is scarce.

Objective

To evaluate changes in antifungal resistance over time.

Design, setting, and participants

Ad hoc analysis of 3 randomized clinical trials including consecutive patients 18 years and older presenting with smear-positive fungal ulcers to Aravind Eye Hospitals in Madurai, Coimbatore, Pondicherry, and Tirunelveli in South India who participated in 1 of 3 clinical trials: the Mycotic Ulcer Treatment Trials (MUTT) I (2010 to 2011) or II (2010 to 2015) or the Cross-Linking Assisted Infection Reduction (CLAIR) trial (2016 to 2018). This post hoc analysis was designed in March 2021 and data were analyzed in May and November 2021.

Int

SUBMITTER: Prajna NV 

PROVIDER: S-EPMC8759027 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature