Pregnancy Outcome in Women With APECED (APS-1): A Multicenter Study on 43 Females With 83 Pregnancies.

ABSTRACT:

Context

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED; also known as autoimmune polyendocrine syndrome type 1) has a severe, unpredictable course. Autoimmunity and disease components may affect fertility and predispose to maternal and fetal complications, but pregnancy outcomes remain unknown.

Objective

To assess fetal and maternal outcomes and course of clinical APECED manifestations during pregnancy in women with APECED.

Design and setting

A multicenter registry-based study including 5 national patient cohorts.

Patients

321 females with APECED.

Main outcome measure

Number of pregnancies, miscarriages, and deliveries.

Results

Forty-three patients had altogether 83 pregnancies at median age of 27 years (range, 17-39). Sixt

SUBMITTER: Laakso S 

PROVIDER: S-EPMC8764323 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature