Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies.

ABSTRACT:

Background

Tauopathies are a group of neurodegenerative diseases associated with the accumulation of misfolded tau protein. The mechanisms underpinning tau-dependent proteinopathy remain to be elucidated. A protein quality control pathway within the endoplasmic reticulum, the unfolded protein response (UPR), has been suggested as a possible pathway modulating cellular responses in a range of neurodegenerative diseases, including those associated with misfolded cytosolic tau.

Objective

In this study we investigated three different clinically defined tauopathies to establish whether these diseases are accompanied by the activation of UPR.

Methods

We used PCR and western blotting to probe for the modulation of several reliable UPR markers in mRNA and proteins extracted f

SUBMITTER: Pitera AP 

PROVIDER: S-EPMC8764631 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature