Exposure to chemical components of fine particulate matter and ozone, and placenta-mediated pregnancy complications in Tokyo: a register-based study.

ABSTRACT:

Background

Maternal exposure to fine particulate matter (PM_2.5) was associated with pregnancy complications. However, we still lack comprehensive evidence regarding which specific chemical components of PM_2.5 are more harmful for maternal and foetal health.

Objective

We focused on exposure over the first trimester (0-13 weeks of gestation), which includes the early placentation period, and investigated whether PM_2.5 and its components were associated with placenta-mediated pregnancy complications (combined outcome of small for gestational age, preeclampsia, placental abruption, and stillbirth).

Methods

From 2013 to 2015, we obtained information, from the Japan Perinatal Registry Network database, on 83,454 women who delivered singleton

SUBMITTER: Michikawa T 

PROVIDER: S-EPMC8770113 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature