Sitafloxacin Expresses Potent Anti-Mycobacterium abscessus Activity.

ABSTRACT: Therapeutic options for treating Mycobacterium abscessus infections are extremely limited; quinolones are important. The in vitro anti-M. abscessus activities of nine quinolones, emphasizing sitafloxacin, were investigated. Antimicrobial susceptibility testing was performed on 10 non-tuberculous mycobacterium reference strains and 194 clinical, M. abscessus isolates. The activity of sitafloxacin against intracellular M. abscessus residing within macrophages was also evaluated. A checkerboard assay was conducted to determine synergy between sitafloxacin and 10 clinically important antibiotics. Among the nine quinolones tested, sitafloxacin exhibited the greatest anti-M. abscessus activity with MIC₅₀ and MIC₉₀ of 1 and 2 mg/L, r

SUBMITTER: He S 

PROVIDER: S-EPMC8770805 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature