A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.

ABSTRACT: Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 severity in an integrated comparison with influenza and sepsis patients versus healthy volunteers. We identify immune signatures and correlates of host response. Hallmarks of disease severity involved cells, their inflammatory mediators and networks, including progenitor cells and specific myeloid and lymphocyte subsets, features of the immune repertoire, acute phase response, metabolism, and coagulation. Persisting immune activation involving AP-1/p38MAPK was a specific feature of COVID-19. The plasma proteome enabled sub-phenotyping into patient clusters, predictive o

SUBMITTER: COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address: [e-mail] 

PROVIDER: S-EPMC8776501 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature