A cross-species comparison of antiretroviral penetration into lymph nodes using novel physiologically based pharmacokinetic models.

ABSTRACT:

Background

Investigating antiretroviral (ARV) penetration and pharmacology in lymph nodes is crucial to understanding mechanisms of HIV persistence in tissue, but sampling these tissues in humans is invasive and costly. Physiologically based pharmacokinetic (PBPK) modelling is a non-invasive solution for understanding lymph node penetration of ARVs across multiple species.

Objectives

To develop customized PBPK models with a novel lymph node compartment, and use these models to describe the distribution of three ARVs-tenofovir, emtricitabine and efavirenz-into the plasma and lymph nodes of non-human primates (NHPs) and humans.

Materials and methods

In this analysis, we utilized standard monkey and human PBPK models in PK-Sim, and added a novel lymph node compartment us

SUBMITTER: Scholz EMB 

PROVIDER: S-EPMC8783597 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature