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Prognostic value of cartilage intermediate layer protein 1 in chronic heart failure.


ABSTRACT:

Aims

Emerging evidence suggests that cartilage intermediate layer protein 1 (CILP-1) is associated with myocardial remodelling. However, the prognostic value of circulating CILP-1 in patients with heart failure (HF) remains to be elucidated. This study aimed to investigate whether circulating CILP-1 can independently predict the outcome of chronic HF.

Methods and results

This prospective cohort study included 210 patients with chronic HF and left ventricular ejection fraction <50% between September 2018 and December 2019. The primary endpoint was 1 year all-cause mortality. During the 1 year follow-up, 28 patients died. In multivariable Cox proportional hazards regression analysis, higher CILP-1 levels were independently associated with a higher risk of mortality after adjusting for potential confounding factors. In Kaplan-Meier analysis, patients with CILP-1 levels above the median had a significantly higher mortality rate than those with CILP-1 levels below the median (log-rank P = 0.015). In addition, CILP-1 significantly improved prognostic prediction over N-terminal pro-brain natriuretic peptide by an increase in net reclassification improvement (P = 0.043) and a trend towards an increase in integrated discrimination improvement (P = 0.118).

Conclusions

Circulating CILP-1 is a novel independent prognostic predictor in chronic HF.

SUBMITTER: Wang C 

PROVIDER: S-EPMC8787959 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Prognostic value of cartilage intermediate layer protein 1 in chronic heart failure.

Wang Can C   Jian Wen W   Luo Qiuhu Q   Cui Jiasheng J   Qing Yali Y   Qin Chunyu C   Li Gaoye G   Chen Wuxian W  

ESC heart failure 20211222 1


<h4>Aims</h4>Emerging evidence suggests that cartilage intermediate layer protein 1 (CILP-1) is associated with myocardial remodelling. However, the prognostic value of circulating CILP-1 in patients with heart failure (HF) remains to be elucidated. This study aimed to investigate whether circulating CILP-1 can independently predict the outcome of chronic HF.<h4>Methods and results</h4>This prospective cohort study included 210 patients with chronic HF and left ventricular ejection fraction <50%  ...[more]

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