Prognostic value of cartilage intermediate layer protein 1 in chronic heart failure.

ABSTRACT:

Aims

Emerging evidence suggests that cartilage intermediate layer protein 1 (CILP-1) is associated with myocardial remodelling. However, the prognostic value of circulating CILP-1 in patients with heart failure (HF) remains to be elucidated. This study aimed to investigate whether circulating CILP-1 can independently predict the outcome of chronic HF.

Methods and results

This prospective cohort study included 210 patients with chronic HF and left ventricular ejection fraction <50% between September 2018 and December 2019. The primary endpoint was 1 year all-cause mortality. During the 1 year follow-up, 28 patients died. In multivariable Cox proportional hazards regression analysis, higher CILP-1 levels were independently associated with a higher risk of mortality after adjus

SUBMITTER: Wang C 

PROVIDER: S-EPMC8787959 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature