Understanding and Harnessing Epithelial‒Mesenchymal Interactions in the Development of Palmoplantar Identity.
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ABSTRACT:
SUBMITTER: Tsai J
PROVIDER: S-EPMC8792145 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Understanding and Harnessing Epithelial‒Mesenchymal Interactions in the Development of Palmoplantar Identity.
Tsai Jerry J Rostom Mary M Garza Luis A LA
The Journal of investigative dermatology 20210806 2
Palmoplantar skin has several unique characteristics such as increased thickness, high resilience, hypopigmentation, and lack of hair follicles. The establishment of palmoplantar identity occurs through keratinocyte‒fibroblast interactions, with keratin 9 expression and Wnt signaling playing key roles. Understanding how palmoplantar features develop may help efforts to reproduce them at both palmoplantar and nonpalmoplantar body sites. ...[more]
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