Polymorphisms of TLR9 gene are associated with a decreased risk of H. pylori infection in a Chinese population.

ABSTRACT:

Background

A series of evidence suggests that genetic variation in toll-like receptor (TLR) 9 might influence the outcome of Helicobacter pylori (H. pylori) infection and play an important role in gastric carcinogenesis.

Methods

We conducted a case-control study to evaluate TLR9 polymorphisms on the risk of H. pylori infection and non-cardia gastric cancer (GC) in a Chinese population. We genotyped a tagging single-nucleotide polymorphism (SNP), rs164640, and a potentially functional SNP, rs187084, by TaqMan technique among 288 patients with non-cardia GC and 281 controls. Unconditional logistic regression (LR) was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for SNPs in association with H. pylori infection and non-cardia GC risk.

Results

Our results indicated that among normal controls, the minor allele homozygotes of both SNPs were significantly associated with a decreased risk of H. pylori infection when compared with their major allele homozygotes (for rs164640: OR =0.41, 95% CI, 0.18-0.93; for 187084: OR =0.38, 95% CI, 0.17-0.85). However, neither of the two SNPs demonstrated a significant association with non-cardia GC risk.

Conclusions

Our results revealed that TLR9 polymorphisms might have effects on the risk of H. pylori infection, but they do not seem to contribute to the risk of non-cardia GC in our studied population.

SUBMITTER: Gao F 

PROVIDER: S-EPMC8798501 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature