Histological study on the influence of puberty suppression and hormonal treatment on developing germ cells in transgender women.
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ABSTRACT:
SUBMITTER: de Nie I
PROVIDER: S-EPMC8804334 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
Histological study on the influence of puberty suppression and hormonal treatment on developing germ cells in transgender women.
de Nie I I Mulder C L CL Meißner A A Schut Y Y Holleman E M EM van der Sluis W B WB Hannema S E SE den Heijer M M Huirne J J van Pelt A M M AMM van Mello N M NM
Human reproduction (Oxford, England) 20220101 2
<h4>Study question</h4>Can transgender women cryopreserve germ cells obtained from their orchiectomy specimen for fertility preservation, after having used puberty suppression and/or hormonal treatment?<h4>Summary answer</h4>In the vast majority of transgender women, there were still immature germ cells present in the orchiectomy specimen, and in 4.7% of transgender women-who all initiated medical treatment in Tanner stage 4 or higher-mature spermatozoa were found, which would enable cryopreserv ...[more]
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