Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer.

ABSTRACT:

Background

Aberrant Wnt signalling, regulating cell development and stemness, influences the development of many cancer types. The Aryl hydrocarbon receptor (AhR) mediates tumorigenesis of environmental pollutants. Complex interaction patterns of genes assigned to AhR/Wnt-signalling were recently associated with lung cancer susceptibility.

Aim

To assess the association and predictive ability of AhR/Wnt-genes with lung cancer in cases and controls of European descent.

Methods

Odds ratios (OR) were estimated for genomic variants assigned to the Wnt agonist and the antagonistic genes DKK2, DKK3, DKK4, FRZB, SFRP4 and Axin2. Logistic regression models with variable selection were trained, validated and tested to predict lung cancer, at which other previously identified SN

SUBMITTER: Rosenberger A 

PROVIDER: S-EPMC8805279 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature