Dichotomous Responses to Chronic Fetal Hypoxia Lead to a Predetermined Aging Phenotype.

ABSTRACT: Hypoxia-induced intrauterine growth restriction increases the risk for cardiovascular, renal, and other chronic diseases in adults, representing thus a major public health problem. Still, not much is known about the fetal mechanisms that predispose these individuals to disease. Using a previously validated mouse model of fetal hypoxia and bottom-up proteomics, we characterize the response of the fetal kidney to chronic hypoxic stress. Fetal kidneys exhibit a dichotomous response to chronic hypoxia, comprising on the one hand cellular adaptations that promote survival (glycolysis, autophagy, and reduced DNA and protein synthesis), but on the other processes that induce a senescence-like phenotype (infiltration of inflammatory cells, DNA damage, and reduced proliferation). Importantly, chron

SUBMITTER: Rudloff S 

PROVIDER: S-EPMC8808178 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature