Apolipoprotein E ε4 Polymorphism as a Risk Factor for Ischemic Stroke: A Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

Rising studies indicate that the apolipoprotein E (APOE) gene is related to the susceptibility of ischemic stroke (IS). However, certain consensus is limited by the lack of a large sample size of researches. This meta-analysis was performed to explore the potential association between the APOE gene and IS.

Methods

To identify relevant case control studies in English publications by October 2020, we searched PubMed, Embase, Web of Science, and the Cochrane Library. Pooled odds ratios (ORs) with fixed- or random-effect models and corresponding 95% confidence intervals (CIs) were calculated to analyze potential associations.

Results

A total of 55 researches from 32 countries containing 12207 IS cases and 27742 controls were included. The association between

SUBMITTER: Qiao SY 

PROVIDER: S-EPMC8831053 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature