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Improvement of High-Throughput Experimentation Using Synthesis Robots by the Implementation of Tailor-Made Sensors.

ABSTRACT: A small, low-cost, self-produced photometer is implemented into a synthesis robot and combined with a modified UV chamber to enable automated sampling and online characterization. In order to show the usability of the new approach, two different reversible addition-fragmentation chain transfer (RAFT) polymers were irradiated with UV light. Automated sampling and subsequent characterization revealed different reaction kinetics depending on polymer type. Thus, a long initiation time (20 min) is required for the end-group degradation of poly(ethylene glycol) ether methyl methacrylate (poly(PEGMEMA)), whereas poly(methyl methacrylate) (PMMA) is immediately converted. Lastly, all photometric samples are characterized via size-exclusion chromatography using UV and RI detectors to prove the results of the self-produced sensor and to investigate the molar mass shift during the reaction.

SUBMITTER: Schuett T

PROVIDER: S-EPMC8838243 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Improvement of High-Throughput Experimentation Using Synthesis Robots by the Implementation of Tailor-Made Sensors.

Schuett Timo T Wejner Manuel M Kimmig Julian J Zechel Stefan S Wilke Timm T Schubert Ulrich S US

Polymers 20220118 3

A small, low-cost, self-produced photometer is implemented into a synthesis robot and combined with a modified UV chamber to enable automated sampling and online characterization. In order to show the usability of the new approach, two different reversible addition-fragmentation chain transfer (RAFT) polymers were irradiated with UV light. Automated sampling and subsequent characterization revealed different reaction kinetics depending on polymer type. Thus, a long initiation time (20 min) is re ...[more]

PMID: 35160352

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