Improvement of High-Throughput Experimentation Using Synthesis Robots by the Implementation of Tailor-Made Sensors.

ABSTRACT: A small, low-cost, self-produced photometer is implemented into a synthesis robot and combined with a modified UV chamber to enable automated sampling and online characterization. In order to show the usability of the new approach, two different reversible addition-fragmentation chain transfer (RAFT) polymers were irradiated with UV light. Automated sampling and subsequent characterization revealed different reaction kinetics depending on polymer type. Thus, a long initiation time (20 min) is required for the end-group degradation of poly(ethylene glycol) ether methyl methacrylate (poly(PEGMEMA)), whereas poly(methyl methacrylate) (PMMA) is immediately converted. Lastly, all photometric samples are characterized via size-exclusion chromatography using UV and RI detectors to prove the resul

SUBMITTER: Schuett T 

PROVIDER: S-EPMC8838243 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature