Pathway Driven Target Selection in Klebsiella pneumoniae: Insights Into Carbapenem Exposure.

ABSTRACT: Carbapenem-resistant Klebsiella pneumoniae (CR-KP) represents an emerging threat to public health. CR-KP infections result in elevated morbidity and mortality. This fact, coupled with their global dissemination and increasingly limited number of therapeutic options, highlights the urgency of novel antimicrobials. Innovative strategies linking genome-wide interrogation with multi-layered metabolic data integration can accelerate the early steps of drug development, particularly target selection. Using the BioCyc ontology, we generated and manually refined a metabolic network for a CR-KP, K. pneumoniae Kp13. Converted into a reaction graph, we conducted topological-based analyses in this network to prioritize pathways exhibiting druggable features and fragile metabolic points l

SUBMITTER: Serral F 

PROVIDER: S-EPMC8841789 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature