A panel of three serum microRNA can be used as potential diagnostic biomarkers for nasopharyngeal carcinoma.

ABSTRACT:

Background

Nasopharyngeal carcinoma is cancer with unique epidemiological characteristics, showing obvious ethnicity, gender, and geographical prevalence. More and more evidence shows that microRNAs are stable in serum and are specific to different tumor types. Therefore, miRNA is a new non-invasive biomarker for cancer detection.

Methods

The experiment is divided into three stages, namely, the screening stage, the training stage, and the verification stage. We took 54 patients with nasopharyngeal carcinoma and 108 healthy controls as the research objects. We use the receiver-operating characteristic (ROC) curve and area under the ROC curve (AUC) to evaluate the diagnostic value of miRNA. Finally, a three-miRNA panel with high diagnostic efficiency was constructed. In additi

SUBMITTER: Li R 

PROVIDER: S-EPMC8842135 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature