Insights on Genetic and Environmental Factors in Parkinson's Disease from a Regional Swedish Case-Control Cohort.

ABSTRACT:

Background

Risk factors for Parkinson's disease (PD) can be more or less relevant to a population due to population-specific genetic architecture, local lifestyle habits, and environmental exposures. Therefore, it is essential to study PD at a local, regional, and continental scale in order to increase the knowledge on disease etiology.

Objective

We aimed to investigate the contribution of genetic and environmental factors to PD in a new Swedish case-control cohort.

Methods

PD patients (n = 929) and matched population-based controls (n = 935) from the southernmost county in Sweden were included in the cohort. Information on environmental exposures was obtained using questionnaires at inclusion. Genetic analyses included a genome-wide association study (GWAS), haplotyp

SUBMITTER: Brolin K 

PROVIDER: S-EPMC8842752 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature