Study of environmental and genetic factors in children with craniosynostosis: A case-control study.

ABSTRACT:

Background

Craniosynostosis is a congenital defect that causes one or more sutures on an infant's skull to close earlier than normal. Though both genetic and environmental factors play a role in its pathogenesis, there is no published Indian data to verify this.

Materials and methods

In this case-control study, we investigated the association of craniosynostosis with parental age in 50 children with craniosynostosis attending the surgical outpatient department of a tertiary care institution in North India.

Results

There was a significant association of craniosynostosis with advanced parental [OR 2.17 (95% CI 1.08 to 4.36)] but not maternal age. Education status of parents also revealed that those having a higher education had an increased risk of having a child with c

SUBMITTER: Barik M 

PROVIDER: S-EPMC3783739 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature