Influence of type I collagen polymorphisms and risk of anterior cruciate ligament rupture in athletes: a case-control study.

ABSTRACT:

Background

Anterior cruciate ligament (ACL) rupture is a common and severe knee injury in sports and occurs mostly due to noncontact injuries. There is an increasing amount of evidence associating ACL rupture to single nucleotide polymorphisms (SNPs), and SNPs in the collagen type I genes can change its expression and tissue mechanical features. This study aimed to investigate the association between SNPs in COL1A1 and COL1A2 with sports-related ACL tears.

Methods

A total of 338 athletes from multiple sports modalities were analyzed: 146 were diagnosed with ACL rupture or underwent an ACL reconstruction surgery and 192 have no musculoskeletal injuries. SNPs were genotyped using validated TaqMan assays. The association of the polymorphisms with ACL rupture was evaluated by a

SUBMITTER: Perini JA 

PROVIDER: S-EPMC8848903 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature