Isolation and Characterization of Novel Lytic Phages Infecting Multidrug-Resistant Escherichia coli.

ABSTRACT: Urinary tract infections (UTIs) are the second most frequent bacterial infections worldwide, with Escherichia coli being the main causative agent. The increase of antibiotic-resistance determinants among isolates from clinical samples, including UTIs, makes the development of novel therapeutic strategies a necessity. In this context, the use of bacteriophages as a therapeutic alternative has been proposed, due to their ability to efficiently kill bacteria. In this work, we isolated and characterized three novel bacteriophages, microbes laboratory phage 1 (MLP1), MLP2, and MLP3, belonging to the Chaseviridae, Myoviridae, and Podoviridae families, respectively. These phages efficiently infect and kill laboratory reference strains and multidrug-resistant clinical E. coli

SUBMITTER: Vera-Mansilla J 

PROVIDER: S-EPMC8849078 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature