High prevalence of HIV-1 transmitted drug resistance and factors associated with time to virological failure and viral suppression in Taiwan.

ABSTRACT:

Background

Integrase strand transfer inhibitor (InSTI)-based regimens have become the major first-line treatment for HIV-1-infected patients in Taiwan. Transmitted drug resistance (TDR) and several clinical characteristics are associated with time to virological failure or viral suppression; however, these have not been investigated in Taiwan.

Objectives

To determine the impact of several factors on treatment outcomes in HIV-1-infected patients in Taiwan.

Methods

The cohort included 164 HIV-1 treatment-naive patients in Taiwan from 2018 to 2020. Blood specimens were collected to determine the genotypic drug resistance using the Stanford University HIV drug resistance database. Cox proportional hazards models were used to identify factors associated with time to virolo

SUBMITTER: Huang SW 

PROVIDER: S-EPMC8851067 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature