Prolonged Islet Allograft Function is Associated With Female Sex in Patients After Islet Transplantation.

ABSTRACT:

Background

Islet transplantation (ITx) has proved to be effective in preventing severe hypoglycemia and improving metabolic control in selected subjects with type 1 diabetes. Long-term graft function remains a challenge. Estrogens have been shown to protect β cells from metabolic stresses and improve revascularization of transplanted human islets in the mouse. We aimed to evaluate the influence of sex in allograft survival of ITx recipients.

Methods

We analyzed a retrospective cohort of ITx recipients (n = 56) followed-up for up to 20 years. Allograft failure was defined as a stimulated C-peptide <0.3 ng/mL during a mixed-meal tolerance test. Subjects were divided into recipients of at least 1 female donor (group 1) and recipients of male donors only (group 2).

Results

SUBMITTER: Lemos JRN 

PROVIDER: S-EPMC8852206 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature